Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hs2st1Gt(pGT1.8TM)ST125Nimr
Name:	heparan sulfate 2-O-sulfotransferase 1; gene trap ST125, National Institute for Medical Research
MGI ID:	MGI:1934916
Synonyms:	Hs2stLacZ, Hs2stTgNSt125Nimr
Gene:	Hs2st1  Location: Chr3:144135467-144275942 bp, - strand  Genetic Position: Chr3, 68.89 cM
Alliance:	Hs2st1Gt(pGT1.8TM)ST125Nimr page

Mutant Cell Line:	ST125
Germline Transmission:	Earliest citation of germline transmission: J:48481
Parent Cell Line:	CGR8 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: pGTtm0     Vector Type: gene trap   Mutation details: A gene trap vector inserted into the coding region of the gene at codon 588. Northern blot analysis demonstrated that a larger hybrid transcript was expressed from this allele, but this transript is not expected to express a functional protein. (J:48481)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hs2st1 Mutation:	33 strains or lines available

Original:	J:48481 Bullock SL, et al., Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Genes Dev. 1998 Jun 15;12(12):1894-906
All:	14 reference(s)