Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il15ratm1Ama
Name:	interleukin 15 receptor, alpha chain; targeted mutation 1, Averil Ma
MGI ID:	MGI:1934016
Synonyms:	Il-15R-, Il15ra-, IL-15Ralpha-, IL-15Ralpha-, RalphaKO
Gene:	Il15ra  Location: Chr2:11709992-11738796 bp, + strand  Genetic Position: Chr2, 8.97 cM
Alliance:	Il15ratm1Ama page

Germline Transmission:	Earliest citation of germline transmission: J:51337
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exons 2 and 3 was replaced by a neomycin resistance cassette. These sequences encode the ligand binding and proline/threonine rich extracellular domains. Northern blot analysis demonstrated that the transcript was not detectable in liver RNA from homozygous mice. (J:51337)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

6 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il15ra Mutation:	39 strains or lines available

Original:	J:51337 Lodolce JP, et al., IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity. 1998 Nov;9(5):669-76
All:	80 reference(s)