Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	H2-K1b-tm1Bpe
Name:	histocompatibility 2, K1, K region; targeted mutation 1, Beatrice Perarnau
MGI ID:	MGI:1931444
Synonyms:	H2-K1tm1Bpe, H2-Kb-, H-2Ko, K-, Kb-
Gene:	H2-K1  Location: Chr17:34214986-34219316 bp, - strand  Genetic Position: Chr17, 17.98 cM
Alliance:	H2-K1b-tm1Bpe page

Germline Transmission:	Earliest citation of germline transmission: J:54709
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The central part of the H2-K gene, including the second and third exons was replaced by a HPRT minigene. (J:41077, J:54709) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

45 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any H2-K1 Mutation:	59 strains or lines available

Original:	J:54709 Perarnau B, et al., Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses. Eur J Immunol. 1999 Apr;29(4):1243-52
All:	146 reference(s)