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Agrntm3Jrs
Targeted Allele Detail
Summary
Symbol: Agrntm3Jrs
Name: agrin; targeted mutation 3, Joshua R Sanes
MGI ID: MGI:1930979
Synonyms: agrndeltaZ, AGZ-
Gene: Agrn  Location: Chr4:156249747-156281945 bp, - strand  Genetic Position: Chr4, 88.55 cM
Alliance: Agrntm3Jrs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55407
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsDeletion of exons 32 and 33, encoding the "z" alternative splice exons as follows: A lox-P flanked neomycin cassette replaced exons 32 and 33, and was excised in ES cells prior to blastocyst injection via Cre-mediated recombination. The final allele has a single loxP site in place of the two exons. (J:55407)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agrn Mutation:  101 strains or lines available
References
Original:  J:55407 Burgess RW, et al., Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction. Neuron. 1999 May;23(1):33-44
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory