Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Crebbptm1Sis Name: CREB binding protein; targeted mutation 1, Shunsuke Ishii MGI ID: MGI:1928768 Synonyms: Cbp-, Crebbptm1Rik Gene: Crebbp  Location: Chr16:3899198-4031864 bp, - strand  Genetic Position: Chr16, 2.4 cM Alliance: Crebbptm1Sis page

Skeletal formation defects in Crebbptm1Sis/Crebbp+ mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:42932
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     The exon encoding amino acids 29-265 was replaced by a neomycin cassette. (J:42932)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	17 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	19 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crebbp Mutation:	99 strains or lines available

Original:	J:42932 Tanaka Y, et al., Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10215-20
All:	9 reference(s)