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Slc9a8 Gene Detail
Summary
  • Symbol
    Slc9a8
  • Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 8
  • Synonyms
    1200006P13Rik, 6430709P13Rik, NHE8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924281
    NCBI Gene: 77031
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:167263632-167318920 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 87.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    272 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924281
protein coding gene Chr2:167261678-167318920 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026912
protein coding gene Chr2:173150247-173213353 (+)
A/J MGP_AJ_G0026879
protein coding gene Chr2:166027391-166083233 (+)
AKR/J MGP_AKRJ_G0026850
protein coding gene Chr2:170977582-171035877 (+)
BALB/cJ MGP_BALBcJ_G0026888
protein coding gene Chr2:166381361-166439219 (+)
C3H/HeJ MGP_C3HHeJ_G0026630
protein coding gene Chr2:171345703-171404660 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027335
protein coding gene Chr2:178196319-178271366 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024706
protein coding gene Chr2:159343342-159399565 (+)
CAST/EiJ MGP_CASTEiJ_G0026088
protein coding gene Chr2:171808132-171869069 (+)
CBA/J MGP_CBAJ_G0026607
protein coding gene Chr2:184729054-184805982 (+)
DBA/2J MGP_DBA2J_G0026745
protein coding gene Chr2:165141366-165196109 (+)
FVB/NJ MGP_FVBNJ_G0026711
protein coding gene Chr2:163662286-163722256 (+)
LP/J MGP_LPJ_G0026846
protein coding gene Chr2:173168954-173230060 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026730
protein coding gene Chr2:188122688-188189986 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027392
protein coding gene Chr2:170904623-170967476 (+)
PWK/PhJ MGP_PWKPhJ_G0025825
protein coding gene Chr2:164800462-164860025 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025626
protein coding gene Chr2:169844354-169906019 (+)
WSB/EiJ MGP_WSBEiJ_G0026161
protein coding gene Chr2:171814292-171873900 (+)



Homology
more
  • Human Ortholog
    SLC9A8, solute carrier family 9 member A8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC9A8, solute carrier family 9 member A8
  • Synonyms
    NHE8, NHE-8
  • Links
    NCBI Gene ID: 23315
    neXtProt AC: NX_Q9Y2E8
    UniProt: Q9Y2E8

  • Chr Location
    20q13.13; chr20:49812713-49892242 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 6 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show male sterility, impaired mucin synthesis and bicarbonate secretion in the colon and elongation of the small intestine, cecum and ileum crypts. Homozygotes for another null allele show male sterility, asthenospermia, globozoospermia, and abnormal acrosome assembly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039463 Ensembl Gene Model | MGI Sequence Detail 55289 C57BL/6J ±  kb
    transcript ENSMUST00000047815 Ensembl | MGI Sequence Detail 4521 Not Applicable  
    polypeptide ENSMUSP00000044185 Ensembl | MGI Sequence Detail 576 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 86
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923489, MGI:2138851
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:299439 Bernardazzi C, et al., An indisputable role of NHE8 in mucosal protection. Am J Physiol Gastrointest Liver Physiol. 2020 Oct 1;319(4):G421-G431

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory