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Arhgap17 Gene Detail
Summary
  • Symbol
    Arhgap17
  • Name
    Rho GTPase activating protein 17
  • Synonyms
    5730403H17Rik, Nadrin, Nadrin2, Rich1, WBP15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917747
    NCBI Gene: 70497
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:122878441-122969138 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 67.42 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    664 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917747
 protein coding gene Chr7:122878372-122969171 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032961
 protein coding gene Chr7:127422788-127514833 (-)
A/J MGP_AJ_G0032944
 protein coding gene Chr7:124110041-124202454 (-)
AKR/J MGP_AKRJ_G0032876
 protein coding gene Chr7:127270213-127360624 (-)
BALB/cJ MGP_BALBcJ_G0032949
 protein coding gene Chr7:123780424-123872749 (-)
C3H/HeJ MGP_C3HHeJ_G0032659
 protein coding gene Chr7:127176958-127270219 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033455
 protein coding gene Chr7:132388159-132480158 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030427
 protein coding gene Chr7:125405272-125498336 (-)
CAST/EiJ MGP_CASTEiJ_G0031987
 protein coding gene Chr7:118987027-119077787 (-)
CBA/J MGP_CBAJ_G0032632
 protein coding gene Chr7:136853058-136945356 (-)
DBA/2J MGP_DBA2J_G0032784
 protein coding gene Chr7:122093136-122184026 (-)
FVB/NJ MGP_FVBNJ_G0032737
 protein coding gene Chr7:121943358-122035037 (-)
LP/J MGP_LPJ_G0032878
 protein coding gene Chr7:128852665-128947141 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032769
 protein coding gene Chr7:138195703-138288443 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033475
 protein coding gene Chr7:126266751-126358439 (-)
PWK/PhJ MGP_PWKPhJ_G0031695
 protein coding gene Chr7:115037862-115129132 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031541
 protein coding gene Chr7:113041188-113132696 (-)
WSB/EiJ MGP_WSBEiJ_G0032100
 protein coding gene Chr7:127176754-127268025 (-)



Homology
more
  • Human Ortholog
    ARHGAP17, Rho GTPase activating protein 17
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP17, Rho GTPase activating protein 17
  • Synonyms
    MST066, MST110, MSTP038, MSTP066, MSTP110, NADRIN, PP367, PP4534, RICH1, RICH-1, WBP15
  • Links
    NCBI Gene ID: 55114
    neXtProt AC: NX_Q68EM7
    UniProt: Q68EM7

  • Chr Location
    16p12.1; chr16:24919389-25015666 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele do not develop spontaneous colitis but show a slight increase in paracellular permeability and increased susceptibility to DSS-induced colitis with rapid destruction of the inner mucus layer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    83
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030766 Ensembl Gene Model | MGI Sequence Detail 90698 C57BL/6J ±  kb
    transcript ENSMUST00000106442 Ensembl | MGI Sequence Detail 3336 Not Applicable  
    polypeptide ENSMUSP00000102050 Ensembl | MGI Sequence Detail 846 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      cDNA 83
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:71028 Bedford MT, et al., A novel pro-Arg motif recognized by WW domains. J Biol Chem. 2000 Apr 7;275(14):10359-69
    • Latest
      J:344526 Wu PR, et al., Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation. Cell Death Dis. 2023 Jan 21;14(1):52
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory