Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	C4btm1Crr
Name:	complement C4B (Chido blood group); targeted mutation 1, Michael C Carroll
MGI ID:	MGI:1889070
Synonyms:	C4-
Gene:	C4b  Location: Chr17:34947354-34962856 bp, - strand  Genetic Position: Chr17, 18.29 cM
Alliance:	C4btm1Crr page

Germline Transmission:	Earliest citation of germline transmission: J:30152
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment corresponding to 987 nucleotides of coding sequence (exons 23-29) was replaced with a neomycin selection cassette. ELISA assays on serum derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:64282)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any C4b Mutation:	102 strains or lines available

Original:	J:30152 Wessels MR, et al., Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11490-4
All:	89 reference(s)