Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Igh-Jtm1Cgn
Name:	immunoglobulin heavy chain, joining region; targeted mutation 1, University of Cologne
MGI ID:	MGI:1861941
Synonyms:	Igh-JHdelta, JH-, JHT, Rr150-Jtm1Cgn
Gene:	Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:64285
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Modified regulatory region, Null/knockout) Mutations:    Insertion, Intergenic deletion   Mutation details: Deletional recombination mediated by cre-loxP resulted in the loss of the exons encoding the joining region and the intron enhancer of the immunoglobulin heavy chain locus (IgH). (J:64285)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Igh-Jtm1Cgn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:	13 strains or lines available

Original:	J:64285 Gu H, et al., Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell. 1993 Jun 18;73(6):1155-64
All:	78 reference(s)