About   Help   FAQ
Pak2Gt(OST104058)Lex
Gene trapped Allele Detail
Summary
Symbol: Pak2Gt(OST104058)Lex
Name: p21 (RAC1) activated kinase 2; gene trap OST104058, Lexicon Genetics
MGI ID: MGI:1861800
Gene: Pak2  Location: Chr16:31835108-31898160 bp, - strand  Genetic Position: Chr16, 22.4 cM
Alliance: Pak2Gt(OST104058)Lex page
Mutation
origin
Mutant Cell Line:  OST104058
Germline Transmission:  Earliest citation of germline transmission: J:46940
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Gene trapped (Null/knockout)
Mutation:    Insertion of gene trap vector
 
Mutation detailsThe gene trap cassette consisting of an long terminal repeat (LTR), splice acceptor sequence (SA), internal ribosome entry site-galactosidase/neomycin phosphotransferase fusion gene (IRES-geo), polyadenylation sequence, phosphoglycerate kinase-1 promoter (PGK), puromycin N-acetyltransferase gene, splice donor sequence (SD), and LTR, inserted before exon 2. Western blot analysis indicates that levels of protein in the hippocampus and cortex are reduced in heterozygotes. (J:271067)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pak2 Mutation:  62 strains or lines available
References
Original:  J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory