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Tap1tm1Hpl
Targeted Allele Detail
Summary
Symbol: Tap1tm1Hpl
Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); targeted mutation 1, Hidde Ploegh
MGI ID: MGI:1858161
Synonyms: TAP10
Gene: Tap1  Location: Chr17:34406530-34416199 bp, + strand  Genetic Position: Chr17, 17.98 cM
Alliance: Tap1tm1Hpl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60782
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequences encoding the second and part of the third transmembrane helices were replaced by a neomycin resistance gene. (J:60782)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Tap1tm1Hpl
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tap1 Mutation:  50 strains or lines available
References
Original:  J:60782 Tourne S, et al., Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1464-9
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory