Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxc4tm1Hsu
Name:	homeobox C4; targeted mutation 1, Hirofumi Suemori
MGI ID:	MGI:1857570
Gene:	Hoxc4  Location: Chr15:102927366-102945278 bp, + strand  Genetic Position: Chr15, 58.08 cM
Alliance:	Hoxc4tm1Hsu page

Germline Transmission:	Earliest citation of germline transmission: J:31635
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 0.6kb of sequence encoding almost all of the homeobox domain. Northern blot analysis did not detect wild-type mRNA transcript in homozygous mutant E12.5 embryos, although an aberrant transcript was detected This raised the possibility that a truncated protein was produced. (J:31635)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxc4 Mutation:	8 strains or lines available

Original:	J:31635 Saegusa H, et al., Targeted disruption in the mouse Hoxc-4 locus results in axial skeleton homeosis and malformation of the xiphoid process. Dev Biol. 1996 Feb 25;174(1):55-64
All:	1 reference(s)