Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Klf1tm1Nimr
Name:	Kruppel-like transcription factor 1 (erythroid); targeted mutation 1, National Institute of Medical Research
MGI ID:	MGI:1857557
Synonyms:	EKLF-
Gene:	Klf1  Location: Chr8:85628611-85631920 bp, + strand  Genetic Position: Chr8, 41.3 cM
Alliance:	Klf1tm1Nimr page

Germline Transmission:	Earliest citation of germline transmission: J:25650
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A LacZ gene and neomycin resistance cassette was inserted in-frame into the genomic sequence just after the initiator ATG codon. This allele expresses beta-galactosidase under the control of the endogenous promoter. (J:25650)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf1 Mutation:	21 strains or lines available

Original:	J:25650 Nuez B, et al., Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature. 1995 May 25;375(6529):316-8
All:	10 reference(s)