Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Cd1tm1Gru
Name:	CD1 antigen complex; targeted mutation 1, Michael Grusby
MGI ID:	MGI:1857482
Synonyms:	CD1-, Cd1d-, Cd1d1/Cd1d2tm1Gru, CD1d KO, CD1tm1Gru
Gene:	Cd1  Location: unknown  Genetic Position: Chr3, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:47769
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intergenic deletion   Cd1tm1Gru involves 2 genes/genome features (Cd1d2, Cd1d1) View all   Mutation details: Both the Cd1d1 gene and the adjacent Cd1d2 gene were mutated in this allele. The coding sequence of Cd1d1 was replaced with a neomycin selection cassette and the coding sequence of Cd1d2 was deleted; however, the intergenic sequence was retained. Flow cytometric analysis on thymocytes derived from homozygous mice confirmed that no stable encoded protein was expressed on the cell surface. (J:47769)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Cd1tm1Gru

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Cd1 Mutation:	7 strains or lines available

Original:	J:47769 Smiley ST, et al., Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science. 1997 Feb 14;275(5302):977-9
All:	123 reference(s)