Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adra2atm1Lel
Name:	adrenergic receptor, alpha 2a; targeted mutation 1, Lee E Limbird
MGI ID:	MGI:1857459
Synonyms:	alpha2A-ARD79N, D79N
Gene:	Adra2a  Location: Chr19:54033690-54037413 bp, + strand  Genetic Position: Chr19, 49.04 cM
Alliance:	Adra2atm1Lel page

Germline Transmission:	Earliest citation of germline transmission: J:34820
Parent Cell Line:	D3H (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Point mutations were introduced to alter the codon at position 79 from one encoding aspartic acid to one encoding asparagine. RNase protection assays indicated that normal levels of transcript were produced from this allele, but binding assays indicated that no functional protein was present in isolated brain membranes of homozygous mice. (J:34820)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adra2a Mutation:	23 strains or lines available

Original:	J:34820 MacMillan LB, et al., Central hypotensive effects of the alpha2a-adrenergic receptor subtype. Science. 1996 Aug 9;273(5276):801-3
All:	16 reference(s)