Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Htr2ctm1Jul
Name:	5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 1, David Julius
MGI ID:	MGI:1857439
Synonyms:	5-HT2cR-deficient
Gene:	Htr2c  Location: ChrX:145745509-145980273 bp, + strand  Genetic Position: ChrX, 68.46 cM, cytoband D-F4
Alliance:	Htr2ctm1Jul page

Germline Transmission:	Earliest citation of germline transmission: J:24339
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129S/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Insertion of a nonsense mutation into exon 5 of the gene resulted in the introduction of a stop codon within the fifth putative transmembrane segment of the receptor and in the elimination of the carboxy-terminal half of the protein. (J:24339)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Htr2c Mutation:	12 strains or lines available

Original:	J:24339 Tecott LH, et al., Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors [see comments]. Nature. 1995 Apr 6;374(6522):542-6
All:	37 reference(s)