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Srctm1Sor
Targeted Allele Detail
Summary
Symbol: Srctm1Sor
Name: Rous sarcoma oncogene; targeted mutation 1, Philippe Soriano
MGI ID: MGI:1857247
Synonyms: src-
Gene: Src  Location: Chr2:157265828-157313758 bp, + strand  Genetic Position: Chr2, 78.35 cM
Alliance: Srctm1Sor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67040
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into the first coding exon. Northern blot analysis confirmed that no wild-type transcript was present in homozygous mice. No autophosphorylation activity corresponding to the encoded protein is detectable in homozygous mice. (J:67040)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 14 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Srctm1Sor
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Src Mutation:  144 strains or lines available
References
Original:  J:67040 Soriano P, et al., Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell. 1991 Feb 22;64(4):693-702
All:  74 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory