Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Lifrtm1Imx
Name:	LIF receptor alpha; targeted mutation 1, Immunex
MGI ID:	MGI:1857213
Synonyms:	LIFR -
Gene:	Lifr  Location: Chr15:7120095-7226970 bp, + strand  Genetic Position: Chr15, 3.46 cM
Alliance:	Lifrtm1Imx page

Germline Transmission:	Earliest citation of germline transmission: J:25253
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion     A lacZ/neomycin cassette replaced the ATG start codon in the targeted construct. (J:25253)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	203 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lifr Mutation:	59 strains or lines available

Original:	J:25253 Ware CB, et al., Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development. 1995 May;121(5):1283-99
All:	12 reference(s)