Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Juntm1Pa
Name:	jun proto-oncogene; targeted mutation 1, Virginia Papaioannou
MGI ID:	MGI:1857209
Synonyms:	c-jun null, Jun-
Gene:	Jun  Location: Chr4:94937273-94940459 bp, - strand  Genetic Position: Chr4, 43.34 cM, cytoband C5-C7
Alliance:	Juntm1Pa page

Germline Transmission:	Earliest citation of germline transmission: J:13175
Parent Cell Line:	PJ5 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into the 5'-untranslated leader sequence of the gene. Southern blots of fetal tissue from homozygous mutants showed no wild-type allele present. Northern blots of embryonic fibroblasts from homozygous mutants showed no detectable mRNA for the targeted gene. (J:13175)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jun Mutation:	12 strains or lines available

Original:	J:13175 Johnson RS, et al., A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 1993 Jul;7(7B):1309-17
All:	7 reference(s)