Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Itgb2tm1Bay Name: integrin beta 2; targeted mutation 1, Baylor College of Medicine MGI ID: MGI:1857208 Synonyms: CD18-, CD18hypo, CD18low, Itgb2hypo Gene: Itgb2  Location: Chr10:77366164-77401542 bp, + strand  Genetic Position: Chr10, 39.72 cM Alliance: Itgb2tm1Bay page

Clinical features and histopathology of psoriasiform skin disease in Itgb2tm1Bay/Itgb2tm1Bay mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:13599
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Hypomorph) Mutation:    Insertion   Mutation details: An insertion mutation that duplicates exons 2 and 3 with interruption of one copy of exon 3 with a neomycin cassette. This is not a null mutation but rather a hypomorph expressing very low levels of ITGB2 protein. (J:13599)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb2 Mutation:	49 strains or lines available

Original:	J:13599 Wilson RW, et al., Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol. 1993 Aug 1;151(3):1571-8
All:	64 reference(s)