Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ighdtm1Cgn
Name:	immunoglobulin heavy constant delta; targeted mutation 1, University of Cologne
MGI ID:	MGI:1857186
Synonyms:	Cdelta, deltaT, IgD-deficient
Gene:	Ighd  Location: Chr12:113371155-113379944 bp, - strand  Genetic Position: Chr12, 62.1 cM
Alliance:	Ighdtm1Cgn page

Germline Transmission:	Earliest citation of germline transmission: J:64281
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a large part of the first exon and inserted a frameshift into the third exon of the constant region of the gene. (J:64281)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ighd Mutation:	19 strains or lines available

Original:	J:64281 Roes J, et al., Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. J Exp Med. 1993 Jan 1;177(1):45-55
All:	5 reference(s)