Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Fn1tm1Hyn
Name:	fibronectin 1; targeted mutation 1, Richard Hynes
MGI ID:	MGI:1857170
Synonyms:	Fn-, FNnull, FN.null
Gene:	Fn1  Location: Chr1:71624679-71692359 bp, - strand  Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
Alliance:	Fn1tm1Hyn page

Germline Transmission:	Earliest citation of germline transmission: J:16247
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced 0.8 kb of the gene including the translation initiation site and part of the signaling sequence. Plasma concentrations of fibronectin in heterozygotes were one-half those of wild-type littermates. The encoded protein was not detectable in immunoprecipitations from cultures of homozygous mutant E7.5 embryos. (J:16247)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

List all tumor models in MMHCdb carrying Fn1tm1Hyn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Fn1 Mutation:	129 strains or lines available

Original:	J:16247 George EL, et al., Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development. 1993 Dec;119(4):1079-91
All:	13 reference(s)