Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Csf3tm1Ard
Name:	colony stimulating factor 3 (granulocyte); targeted mutation 1, Ashley R Dunn
MGI ID:	MGI:1857155
Synonyms:	G-CSF-
Gene:	Csf3  Location: Chr11:98592089-98594455 bp, + strand  Genetic Position: Chr11, 62.45 cM
Alliance:	Csf3tm1Ard page

Germline Transmission:	Earliest citation of germline transmission: J:20400
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A 0.7kb genomic fragment containing exons 1-3 was replaced by a lacZ gene and neomycin resistance cassette. This mutation placed the lacZ gene under the control of the Csf3 promoter elements. An activity assay demonstrated that the functional protein was not detectable in cultured medium derived from organ cultures of various tissues of homozygous mice. (J:20400)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Csf3 Mutation:	17 strains or lines available

Original:	J:20400 Lieschke GJ, et al., Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood. 1994 Sep 15;84(6):1737-46
All:	32 reference(s)