Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Asgr2tm1Her
Name:	asialoglycoprotein receptor 2; targeted mutation 1, Joachim Herz
MGI ID:	MGI:1857130
Synonyms:	ASGP-R2-, HL-2 -
Gene:	Asgr2  Location: Chr11:69983470-69997013 bp, + strand  Genetic Position: Chr11, 42.99 cM
Alliance:	Asgr2tm1Her page

Germline Transmission:	Earliest citation of germline transmission: J:21380
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that the transcript was not detectable in liver RNA from homozygous mice. The protein was also not detected in liver membrane protein fractions derived from homozygous mice. (J:21380)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Asgr2 Mutation:	20 strains or lines available

Original:	J:21380 Ishibashi S, et al., Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit. J Biol Chem. 1994 Nov 11;269(45):27803-6
All:	9 reference(s)