Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	MipCat-Lop
Name:	major intrinsic protein of lens fiber; cataract lens opacity
MGI ID:	MGI:1857105
Gene:	Mip  Location: Chr10:128061707-128067681 bp, + strand  Genetic Position: Chr10, 76.49 cM, cytoband D1
Alliance:	MipCat-Lop page

Strain of Origin:

STOCK Rb(6.15)1Ald

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: A G-to-C transversion at position 151 of the encoded mRNA results in a non-conservative change at amino acid 51 from alanine to proline (p.A51P). This mutation inhibits targeting of the mutant product to the cell membrane. (J:31574) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mip Mutation:	31 strains or lines available

Original:	J:6702 Lyon MF, et al., Lens opacity: a new gene for congenital cataract on chromosome 10 of the mouse. Genet Res. 1981 Dec;38(3):337-41
All:	4 reference(s)