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Nototc
Spontaneous Allele Detail
Summary
Symbol: Nototc
Name: notochord homeobox; truncate
MGI ID: MGI:1857063
Synonyms: bo, boneless, boneless tail, jt, tc
Gene: Noto  Location: Chr6:85400868-85405859 bp, + strand  Genetic Position: Chr6, 37.44 cM
Alliance: Nototc page
Mutation
origin
Strain of Origin:  Swiss albino stock
Mutation
description
Allele Type:    Spontaneous (Hypomorph)
Mutation:    Single point mutation
 
Mutation detailsA T-to-G transversion causes a phenylalanine to cysteine substitution in position 168 ( amino-acid 20 of helix 1 of the homeodomain) (p.F168C). This allele is hypomorphic. (J:91405)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 26 assay results
In Structures Affected by this Mutation: 13 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Noto Mutation:  15 strains or lines available
References
Original:  J:64444 Griffen A, tc - truncate. Mouse News Lett. 1951;5:31
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory