Grem1<ld> Radiation induced Allele Detail MGI Mouse (MGI:1856289)

Grem1^ld
Radiation induced Allele Detail

Summary

Symbol:	Grem1^ld
Name:	gremlin 1, DAN family BMP antagonist; limb deformity
MGI ID:	MGI:1856289
Synonyms:	Fmn^ld, Fmn^ld-Or, ld, ld^OR
Gene:	Grem1 Location: Chr2:113579020-113588993 bp, - strand Genetic Position: Chr2, 57.43 cM
Alliance:	Grem1^ld page

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:		Radiation induced
Mutation:		Intragenic deletion
		Mutation details: This mutant allele was recovered at The Oak Ridge National Laboratory among descendants of an X-irradiated male. The allele contains a 12.7 kb deletion that eliminates the entire open reading frame encoded by exon 2. (J:13658, J:43337, J:91385)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Grem1 Mutation:	16 strains or lines available

Notes

Possibly radiation induced (found in later generation descendants of X-irradiated male).

Originally called "severe appendicular abnormality."

This limb deformity allele was determined through complementation analysis to be allelic to limb deformity Jackson (Grem1^ld-J; J:22160), Fmn1^ld-TgBri137 (J:1741), and Fmn1^{ld-Is(17;In2)1Gso} (J:10399).

References

Original:	J:22158 Cupp MB, Severe appendicular abnormality. Mouse News Lett. 1958;19:37
All:	16 reference(s)

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