Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Otcspf Name: ornithine transcarbamylase; sparse fur MGI ID: MGI:1856178 Synonyms: spf Gene: Otc  Location: ChrX:10118584-10187275 bp, + strand  Genetic Position: ChrX, 4.66 cM, cytoband A1 Alliance: Otcspf page

Otcspf/Otcspf Show the 1 phenotype image(s) involving this allele.

Strain of Origin:

Not Specified

Allele Type:    Radiation induced (Hypomorph) Mutation:    Single point mutation   Mutation details: A C to A missense transversion mutation in exon 4 changes a histidine to asparagine (H117N), creating a hypomorphic allele. About 10% of normal liver enzyme activity remains in mutant mice. (J:8786) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any Otc Mutation:	22 strains or lines available

Original:	J:26975 Cupp MB, Sparse-fur, Sf. Mouse News Lett. 1958;19:37
All:	33 reference(s)