Pou1f1<dw-J> Spontaneous Allele Detail MGI Mouse (MGI:1856025)

Pou1f1^dw-J
Spontaneous Allele Detail

Summary

Symbol:	Pou1f1^dw-J
Name:	POU domain, class 1, transcription factor 1; dwarf Jackson
MGI ID:	MGI:1856025
Synonyms:	dwarf-J, dwJ, Pit1^dwJ
Gene:	Pou1f1 Location: Chr16:65317397-65331183 bp, + strand Genetic Position: Chr16, 37.25 cM
Alliance:	Pou1f1^dw-J page

Mutation
origin

Strain of Origin:

C3H/HeJ

Mutation
description

Allele Type:		Spontaneous
Mutation:		Other
		Mutation details: The mutation was characterized by Southern blot as either a chromosomal inversion or an insertion of greater than 4kb in the gene. PCR analysis revealed that most of exon 3 is intact, but the exact break points are not established. (J:10774, J:10998)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Pou1f1 Mutation:	21 strains or lines available

Notes

This remutation of the Snell dwarf gene occurred in the C3H/HeJ strain (J:6342). Mutant mice homozygous for Pit1^dw-J, like homozygotes for Pit1^dw, lack PIT1 protein activity and have no lactotrophs, thyrotrophs, or somatotrophs (J:10774).

References

Original:	J:6342 Eicher EM, et al., New mouse dw allele: genetic location and effects on lifespan and growth hormone levels. J Hered. 1980 May-Jun;71(3):187-90
All:	19 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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