Lepr<db-ad> Spontaneous Allele Detail MGI Mouse (MGI:1856011)

Lepr^db-ad
Spontaneous Allele Detail

Summary

Symbol:	Lepr^db-ad
Name:	leptin receptor; adipose
MGI ID:	MGI:1856011
Gene:	Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
Alliance:	Lepr^db-ad page

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:		Spontaneous
Mutation:		Undefined
		Mutation details: This allele arose spontaneously in a stock selected for large body size derived from a cross between the Goodale and MacArthur Large selected populations. It was shown to be allelic to Lepr^db. (J:27525)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Lepr Mutation:	121 strains or lines available

Notes

Lepr^db-ad, adipose, recessive. This allele arose spontaneously in a stock selected for large body size derived from a cross between the Goodale and MacArthur Large selected populations (J:31691). It was shown to be allelic to Lepr^db (J:27525). Like other mutations at the Lepr locus, homozygotes for adipose show a phenotype very similar to that of Lepr^db homozygotes, differences being no greater than might be caused by differences in genetic background.

References

Original:	J:31691 Falconer DS, et al., Adipose, a new inherited obesity of the mouse. J Hered. 1959;50(6):290-292
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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