Tyrp1<b-c> Spontaneous Allele Detail MGI Mouse (MGI:1855961)

Tyrp1^b-c
Spontaneous Allele Detail

Summary

Symbol:	Tyrp1^b-c
Name:	tyrosinase-related protein 1; brown cordovan
MGI ID:	MGI:1855961
Synonyms:	Tyrp1^b-cJ
Gene:	Tyrp1 Location: Chr4:80752360-80769956 bp, + strand Genetic Position: Chr4, 37.89 cM
Alliance:	Tyrp1^b-c page

Mutation
origin

Strain of Origin:

(DBA/1 x C57BL/10)F1

Mutation
description

Allele Type:		Spontaneous
Mutation:		Undefined
		Mutation details: Complementation testing demonstrated that this mutation is an allele of the original brown (Tyrp1^b) mutation. The Tyrp1^b-c allele was found among (DBA/1 X C57BL/10)F1 offspring. Because DBA is homozygous for Tyrp1^b, the mutation occurred on C57BL10.
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Tyrp1 Mutation:	162 strains or lines available

Notes

Homozygous recessive mutant on a nonagouti/black background are chocolate brown and show altered melanin granule morphology. Semidominant mutants result in melanocyte degeneration causing reduced pigmentation and progressive hearing loss.

References

Original:	J:15167 Miller DS, et al., Cordovan, a new allele of black and brown color in the mouse. J Hered. 1955;46(6):293-96
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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