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Akt3 Gene Detail
Summary
  • Symbol
    Akt3
  • Name
    thymoma viral proto-oncogene 3
  • Synonyms
    D930002M15Rik, Nmf350, PKB gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345147
    NCBI Gene: 23797
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:176847639-177085769 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 82.66 cM, cytoband H4-H6
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    723 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345147
 protein coding gene Chr1:176847639-177091688 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016847
 protein coding gene Chr1:183176436-183423409 (-)
A/J MGP_AJ_G0016826
 protein coding gene Chr1:175787463-176033472 (-)
AKR/J MGP_AKRJ_G0016792
 protein coding gene Chr1:181048260-181296144 (-)
BALB/cJ MGP_BALBcJ_G0016783
 protein coding gene Chr1:176315226-176554560 (-)
C3H/HeJ MGP_C3HHeJ_G0016609
 protein coding gene Chr1:181654999-181900894 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017248
 protein coding gene Chr1:189210189-189458695 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014954
 protein coding gene Chr1:167072951-167310088 (-)
CAST/EiJ MGP_CASTEiJ_G0016190
 protein coding gene Chr1:181033347-181276024 (-)
CBA/J MGP_CBAJ_G0016582
 protein coding gene Chr1:196091733-196353993 (-)
DBA/2J MGP_DBA2J_G0016688
 protein coding gene Chr1:174653114-174893232 (-)
FVB/NJ MGP_FVBNJ_G0016685
 protein coding gene Chr1:172742225-172980152 (-)
LP/J MGP_LPJ_G0016763
 protein coding gene Chr1:184368124-184603245 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016716
 protein coding gene Chr1:203323401-203603481 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017284
 protein coding gene Chr1:180778812-181036339 (-)
PWK/PhJ MGP_PWKPhJ_G0015977
 protein coding gene Chr1:173730799-173977400 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015754
 protein coding gene Chr1:179886729-180134359 (-)
WSB/EiJ MGP_WSBEiJ_G0016252
 protein coding gene Chr1:181012761-181254681 (-)



Homology
more
  • Human Ortholog
    AKT3, AKT serine/threonine kinase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKT3, AKT serine/threonine kinase 3
  • Synonyms
    MPPH, MPPH2, PKBG, PKB-GAMMA, PRKBG, RAC-gamma, RAC-PK-gamma, STK-2
  • Links
    NCBI Gene ID: 10000
    neXtProt AC: NX_Q9Y243
    UniProt: Q9Y243

  • Chr Location
    1q43-q44; chr1:243488233-243851079 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human AKT3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 5 genetic backgrounds
    20 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a 20% decrease in brain size and have smaller and fewer cells in the brain. Mice heterozygous for an ENU-induced mutation exhibit increased seizures (sporadic and induced) and increased brain weight and size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    945
  • Tissues
    86
  • cDNA Data
    11
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019699 Ensembl Gene Model | MGI Sequence Detail 238131 C57BL/6J ±  kb
    transcript ENSMUST00000111159 Ensembl | MGI Sequence Detail 4906 Not Applicable  
    polypeptide ENSMUSP00000106789 Ensembl | MGI Sequence Detail 479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 12
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138357, MGI:3628555
    References
    more
    • Summaries
      All 138
      Developmental Gene Expression 30
      Gene Ontology 14
      Phenotypes 58
    • Earliest
      J:54026 Brodbeck D, et al., A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem. 1999 Apr 2;274(14):9133-6
    • Latest
      J:327336 Bertol JW, et al., TWIST1 interacts with beta/delta-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development. 2022 Aug 1;149(15):dev200068
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory