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Slc6a18 Gene Detail
Summary
  • Symbol
    Slc6a18
  • Name
    solute carrier family 6 (neurotransmitter transporter), member 18
  • Synonyms
    D630001K16Rik, XT2, Xtrp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336892
    NCBI Gene: 22598
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:73809871-73826142 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 40.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336892
 protein coding gene Chr13:73809869-73826142 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020749
 protein coding gene Chr13:74129633-74149722 (-)
A/J MGP_AJ_G0020705
 protein coding gene Chr13:71484409-71500638 (-)
AKR/J MGP_AKRJ_G0020679
 protein coding gene Chr13:73731442-73747669 (-)
BALB/cJ MGP_BALBcJ_G0020702
 protein coding gene Chr13:71975422-71992058 (-)
C3H/HeJ MGP_C3HHeJ_G0020496
 protein coding gene Chr13:73411961-73429587 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021139
 protein coding gene Chr13:76600485-76617836 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018706
 protein coding gene Chr13:68303376-68320046 (-)
CAST/EiJ MGP_CASTEiJ_G0020013
 protein coding gene Chr13:72491982-72509929 (-)
CBA/J MGP_CBAJ_G0020455
 protein coding gene Chr13:79448287-79467731 (-)
DBA/2J MGP_DBA2J_G0020580
 protein coding gene Chr13:71305186-71321441 (-)
FVB/NJ MGP_FVBNJ_G0020560
 protein coding gene Chr13:70326384-70344341 (-)
LP/J MGP_LPJ_G0020653
 protein coding gene Chr13:74372478-74389753 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020588
 protein coding gene Chr13:77878136-77895360 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021178
 protein coding gene Chr13:73040775-73057013 (-)
PWK/PhJ MGP_PWKPhJ_G0019767
 protein coding gene Chr13:70039640-70056096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019590
 protein coding gene Chr13:69508238-69524458 (-)
WSB/EiJ MGP_WSBEiJ_G0020071
 protein coding gene Chr13:73587667-73606510 (-)



Homology
more
  • Human Ortholog
    SLC6A18, solute carrier family 6 member 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC6A18, solute carrier family 6 member 18
  • Synonyms
    Xtrp2
  • Links
    NCBI Gene ID: 348932
    neXtProt AC: NX_Q96N87
    UniProt: Q96N87

  • Chr Location
    5p15.33; chr5:1225381-1246189 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are overtly normal but have increased blood pressure associated with impaired renal accumulation of glycine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    70
  • cDNA Data
    60
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021612 Ensembl Gene Model | MGI Sequence Detail 16272 C57BL/6J ±  kb
    transcript ENSMUST00000222029 Ensembl | MGI Sequence Detail 2005 Not Applicable  
    polypeptide ENSMUSP00000152525 Ensembl | MGI Sequence Detail 615 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015184 inactive sodium-dependent neutral amino acid transporter B(0)AT3
      (term hierarchy)
    • InterPro Domains
      IPR042701 B0AT3, solute-binding domain
      IPR002438 Neutral amino acid SLC6 transporter
      IPR000175 Sodium:neurotransmitter symporter
      IPR037272 Sodium:neurotransmitter symporter superfamily
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 1
      cDNA 60

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2444902
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:238554 Kaminski MM, et al., Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors. Nat Cell Biol. 2016 Dec;18(12):1269-1280
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory