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Hells Gene Detail
Summary
  • Symbol
    Hells
  • Name
    helicase, lymphoid specific
  • Synonyms
    E130115I21Rik, LSH, Lysh, PASG, proliferation-associated SNF2-like, YFK8
  • Feature Type
    protein coding gene
  • IDs
    MGI:106209
    NCBI Gene: 15201
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:38919359-38959495 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 33.57 cM, cytoband C3-D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    807 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106209
 protein coding gene Chr19:38913282-38959495 (+)
129S1/SvImJ ENSMUSG00200027372
 protein coding gene Chr19:35711046-35751112 (+)
A/J ENSMUSG00195010495
 protein coding gene Chr19:35810736-35850827 (+)
AKR/J ENSMUSG00220018779
 protein coding gene Chr19:35692294-35732386 (+)
BALB/cJ ENSMUSG00180028938
 protein coding gene Chr19:36138686-36178774 (+)
C3H/HeJ ENSMUSG00175036094
 protein coding gene Chr19:35568326-35608419 (+)
C57BL/6NJ ENSMUSG00215015515
 protein coding gene Chr19:35586497-35626634 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022930
 protein coding gene Chr19:35493046-35532834 (+)
CAST/EiJ ENSTCUG00005014348
 protein coding gene Chr19:35243308-35283229 (+)
CBA/J ENSMUSG00210027968
 protein coding gene Chr19:35647581-35687674 (+)
DBA/2J ENSMUSG00185031276
 protein coding gene Chr19:36167731-36207836 (+)
FVB/NJ ENSMUSG00205006630
 protein coding gene Chr19:35415652-35455734 (+)
JF1/MsJ ENSUMUG00000032712
 protein coding gene Chr19:36314251-36354326 (+)
LP/J ENSMUSG00230033352
 protein coding gene Chr19:36982784-37022848 (+)
NOD/ShiLtJ ENSMUSG00190009584
 protein coding gene Chr19:35548842-35588905 (+)
NZO/HlLtJ ENSMUSG00225041608
 protein coding gene Chr19:40532692-40572754 (+)
PWK/PhJ ENSLUMG00010001009
 protein coding gene Chr19:35690571-35730668 (+)
SPRET/EiJ ENSMSPG00010021957
 protein coding gene Chr19:35428946-35467016 (+)
WSB/EiJ ENSIUOG00005033197
 protein coding gene Chr19:35056713-35096822 (+)



Homology
more
  • Human Ortholog
    HELLS, helicase, lymphoid specific
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HELLS, helicase, lymphoid specific
  • Synonyms
    ICF4, LSH, Nbla10143, PASG, SALNR, SMARCA6
  • Links
    NCBI Gene ID: 3070
    UniProt: Q9NRZ9

  • Chr Location
    10q23.33; chr10:94545329-94613905 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HELLS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    65 phenotypes from 6 alleles in 6 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show DNA hypomethylation, delayed growth, multiorgan and skeletal defects, premature graying, alopecia, low fat deposition, kyphosis, cachexia and early death. Homozygotes for another null allele show neonatal death, low birth weight, lymphoid defects and renal lesions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    657
  • Tissues
    40
  • cDNA Data
    13
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025001 Ensembl Gene Model | MGI Sequence Detail 40137 C57BL/6J ±  kb
    transcript ENSMUST00000025965 Ensembl | MGI Sequence Detail 5868 Not Applicable  
    polypeptide ENSMUSP00000025965 Ensembl | MGI Sequence Detail 821 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 5
      cDNA 16
      Primer pair 1
      Other 1
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33900, MGD-MRK-33901, MGI:106208, MGI:1925121, MGI:2147507
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 13
      Gene Ontology 21
      Phenotypes 36
    • Earliest
      J:32111 Jarvis CD, et al., A novel putative helicase produced in early murine lymphocytes. Gene. 1996 Mar 9;169(2):203-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory