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Lrrn2 Gene Detail
Summary
  • Symbol
    Lrrn2
  • Name
    leucine rich repeat protein 2, neuronal
  • Synonyms
    5730406J09Rik, NLRR-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106037
    NCBI Gene: 16980
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:132808093-132867743 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.69 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    474 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106037
protein coding gene Chr1:132808011-132867743 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016477
protein coding gene Chr1:136386653-136446111 (+)
A/J MGP_AJ_G0016460
protein coding gene Chr1:131327125-131386850 (+)
AKR/J MGP_AKRJ_G0016425
protein coding gene Chr1:135188918-135250103 (+)
BALB/cJ MGP_BALBcJ_G0016420
protein coding gene Chr1:131662322-131721865 (+)
C3H/HeJ MGP_C3HHeJ_G0016246
protein coding gene Chr1:135338541-135398221 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016881
protein coding gene Chr1:141438555-141498485 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014592
protein coding gene Chr1:124483146-124544313 (+)
CAST/EiJ MGP_CASTEiJ_G0015826
protein coding gene Chr1:134346065-134406887 (+)
CBA/J MGP_CBAJ_G0016218
protein coding gene Chr1:146269924-146329539 (+)
DBA/2J MGP_DBA2J_G0016325
protein coding gene Chr1:130294136-130354127 (+)
FVB/NJ MGP_FVBNJ_G0016324
protein coding gene Chr1:128939258-128999782 (+)
LP/J MGP_LPJ_G0016396
protein coding gene Chr1:137701064-137761951 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016349
protein coding gene Chr1:152058396-152118096 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016917
protein coding gene Chr1:134952959-135012529 (+)
PWK/PhJ MGP_PWKPhJ_G0015612
protein coding gene Chr1:129285973-129348137 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015399
protein coding gene Chr1:133899695-133962567 (+)
WSB/EiJ MGP_WSBEiJ_G0015888
protein coding gene Chr1:134950087-135009693 (+)



Homology
more
  • Human Ortholog
    LRRN2, leucine rich repeat neuronal 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRN2, leucine rich repeat neuronal 2
  • Synonyms
    FIGLER7, GAC1, LRANK1, LRRN5
  • Links
    NCBI Gene ID: 10446
    neXtProt AC: NX_O75325
    UniProt: O75325

  • Chr Location
    1q32.1; chr1:204617170-204685738 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibited numerous neurological abnormalities when compared with controls.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16980 NCBI Gene Model | MGI Sequence Detail 59651 C57BL/6J ±  kb
transcript NM_010732 RefSeq | MGI Sequence Detail 3346 C57BL/6  
polypeptide NP_034862 RefSeq | MGI Sequence Detail 730 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 37
    Primer pair 1
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-33721, MGI:1925383
References
more
  • Summaries
    All 39
    Developmental Gene Expression 7
    Gene Ontology 1
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory