Mobq3 MGI Mouse QTL Detail - MGI:105951 - multigenic obesity QTL 3

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Mobq3 QTL Detail

Symbol

Mobq3
Name

multigenic obesity QTL 3
Synonyms

Mob3

Feature Type

QTL
IDs

MGI:105951
NCBI Gene: 112065
Candidate Genes

1 Gene

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Sequence Map

Chr12:106664071-106664351 bp
From MGI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 57.30 cM (cM position of peak correlated region/marker)
Mapping Data

2 experiments

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype reference

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
QTL

2
Find Mice (IMSR)

0 strains or lines available

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NCBI Gene

112065

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MGD-MRK-33630

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Summaries

All 4

Phenotypes 1
Earliest

J:24238 Warden CH, et al., Identification of four chromosomal loci determining obesity in a multifactorial mouse model. J Clin Invest. 1995 Apr;95(4):1545-52
Latest

J:91835 Kaput J, et al., Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics. 2004 Aug 11;18(3):316-24

Candidate Genes for Mobq3:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Gsc	Chr12:104437468-104439495 (-)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 12, Gsc (52 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTLs Dbsty3 (48 cM) and Mob3 (53 cM) map near candidate gene Gsc.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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