Mgat3 MGI Mouse Gene Detail - MGI:104532 - mannoside acetylglucosaminyltransferase 3

Symbol

Mgat3
Name

mannoside acetylglucosaminyltransferase 3
Synonyms

1110038J12Rik, GnT-III

Feature Type

protein coding gene
IDs

MGI:104532
NCBI Gene: 17309
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr15:80057922-80099720 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.85 cM, cytoband E
Mapping Data

5 experiments

SNPs within 2kb

274 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104532	protein coding gene	Chr15:80057852-80099720 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022095	protein coding gene	Chr15:80496565-80547517 (+)
A/J	MGP_AJ_G0022056	protein coding gene	Chr15:77705911-77747550 (+)
AKR/J	MGP_AKRJ_G0022031	protein coding gene	Chr15:79874992-79919319 (+)
BALB/cJ	MGP_BALBcJ_G0022062	protein coding gene	Chr15:77713340-77756557 (+)
C3H/HeJ	MGP_C3HHeJ_G0021833	protein coding gene	Chr15:79871227-79914493 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022505	protein coding gene	Chr15:83662557-83707828 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020035	protein coding gene	Chr15:74186854-74235698 (+)
CAST/EiJ	MGP_CASTEiJ_G0021354	protein coding gene	Chr15:80587328-80633164 (+)
CBA/J	MGP_CBAJ_G0021798	protein coding gene	Chr15:86320279-86361657 (+)
DBA/2J	MGP_DBA2J_G0021927	protein coding gene	Chr15:77198213-77240456 (+)
FVB/NJ	MGP_FVBNJ_G0021905	protein coding gene	Chr15:76218469-76261784 (+)
LP/J	MGP_LPJ_G0021995	protein coding gene	Chr15:80677657-80720518 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021925	protein coding gene	Chr15:91334455-91384180 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022519	protein coding gene	Chr15:79911275-79955676 (+)
PWK/PhJ	MGP_PWKPhJ_G0021096	protein coding gene	Chr15:77210163-77254673 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020933	protein coding gene	Chr15:79712482-79763843 (+)
WSB/EiJ	MGP_WSBEiJ_G0021406	protein coding gene	Chr15:80315893-80360678 (+)

Human Ortholog

MGAT3, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MGAT3, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Synonyms

GNT3, GNT-III
Links

HGNC:7046

NCBI Gene ID: 4248

neXtProt AC: NX_Q09327

UniProt: Q09327
Chr Location

22q13.1; chr22:39457012-39492194 (+) GRCh38

MGI Vertebrate Homology

Mgat3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MGAT3
Gene Tree

Mgat3

less

References

1 with disease annotations

less

Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Mgat3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced DEN and PB-induced hepatic tumors and reduced hepatocyte proliferation.

less

All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

106
cDNA Data

44
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MGAT3

Xenbase mgat3

ZFIN mgat3a

less

All Sequences

50
RefSeq

16
UniProt

2
CCDS

CCDS27660.1

Ensembl

ENSMUSG00000042428 (Evidence)
NCBI Gene

17309

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042428	Ensembl Gene Model \| MGI Sequence Detail	41799	C57BL/6J	± kb
transcript	ENSMUST00000044970	Ensembl \| MGI Sequence Detail	4665	Not Applicable
polypeptide	ENSMUSP00000043077	Ensembl \| MGI Sequence Detail	538	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000010380 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

(term hierarchy)
InterPro Domains

IPR006813 Glycosyl transferase, family 17

less

All nucleic 50

Genomic 6

cDNA 44

Microarray probesets 4

less

MGD-MRK-25963, MGI:1916016, MGI:2146079

Summaries

All 69

Developmental Gene Expression 2

Diseases 1

Gene Ontology 8

Phenotypes 37
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Mgat3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132171	Chr15:80056096-80056113 (+)	-1,817 bp
Tssr132172	Chr15:80057389-80057405 (+)	-525 bp
Tssr132173	Chr15:80057406-80057430 (+)	-504 bp
Tssr132174	Chr15:80057451-80057468 (+)	-462 bp
Tssr132175	Chr15:80057471-80057501 (+)	-436 bp
Tssr132176	Chr15:80057505-80057611 (+)	-364 bp
Tssr132177	Chr15:80057716-80057749 (+)	-189 bp
Tssr132178	Chr15:80057753-80057781 (+)	-155 bp
Tssr132179	Chr15:80057786-80057802 (+)	-128 bp
Tssr132180	Chr15:80057843-80057884 (+)	-58 bp
Tssr132181	Chr15:80057894-80057905 (+)	-22 bp
Tssr132182	Chr15:80057979-80058013 (+)	74 bp
Tssr132183	Chr15:80073333-80073383 (+)	15,436 bp
Tssr132184	Chr15:80073385-80073402 (+)	15,472 bp
Tssr132185	Chr15:80076046-80076079 (+)	18,141 bp
Tssr132186	Chr15:80076363-80076383 (+)	18,451 bp
Tssr132187	Chr15:80077201-80077215 (+)	19,286 bp
Tssr132188	Chr15:80077254-80077271 (+)	19,341 bp
Tssr132189	Chr15:80077274-80077286 (+)	19,358 bp
Tssr4660	Chr15:80077311-80077333 (+)	19,400 bp
Tssr132190	Chr15:80096313-80096338 (+)	38,404 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23