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Tmem161b Gene Detail
Summary
  • Symbol
    Tmem161b
  • Name
    transmembrane protein 161B
  • Synonyms
    2810446P07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919995
    NCBI Gene: 72745
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:84370415-84444085 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 44.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    412 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919995
 protein coding gene Chr13:84370415-84444260 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020792
 protein coding gene Chr13:85116002-85199386 (+)
A/J MGP_AJ_G0020748
 protein coding gene Chr13:82126704-82200936 (+)
AKR/J MGP_AKRJ_G0020721
 protein coding gene Chr13:84570992-84652570 (+)
BALB/cJ MGP_BALBcJ_G0020744
 protein coding gene Chr13:82681982-82755722 (+)
C3H/HeJ MGP_C3HHeJ_G0020538
 protein coding gene Chr13:84270156-84348223 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021181
 protein coding gene Chr13:87822700-87900285 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018749
 protein coding gene Chr13:78473927-78544351 (+)
CAST/EiJ MGP_CASTEiJ_G0020056
 protein coding gene Chr13:83380318-83458532 (+)
CBA/J MGP_CBAJ_G0020497
 protein coding gene Chr13:91156193-91243934 (+)
DBA/2J MGP_DBA2J_G0020622
 protein coding gene Chr13:81774238-81848668 (+)
FVB/NJ MGP_FVBNJ_G0020602
 protein coding gene Chr13:80820743-80895905 (+)
LP/J MGP_LPJ_G0020695
 protein coding gene Chr13:85337458-85413793 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020631
 protein coding gene Chr13:90435687-90515174 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021221
 protein coding gene Chr13:83947587-84028346 (+)
PWK/PhJ MGP_PWKPhJ_G0019809
 protein coding gene Chr13:80688795-80762995 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019632
 protein coding gene Chr13:80277399-80361081 (+)
WSB/EiJ MGP_WSBEiJ_G0020113
 protein coding gene Chr13:84404075-84484083 (+)



Homology
more
  • Human Ortholog
    TMEM161B, transmembrane protein 161B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM161B, transmembrane protein 161B
  • Synonyms
    FLB3342, PRO1313
  • Links
    NCBI Gene ID: 153396
    neXtProt AC: NX_Q8NDZ6
    UniProt: Q8NDZ6

  • Chr Location
    5q14.3; chr5:88185570-88269476 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 5 alleles in 7 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice exhibit lethality before weaning and leads to holoprosencephaly and craniofacial, cerebral cortex stratification and retina pigment epithelium abnormalities in embryos. Heterozygous KO leads to decreased circulating serum albumin and total protein levels and bone mineral content, lower lean body mass and higher total body fat amount.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    34
  • cDNA Data
    31
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72745 NCBI Gene Model | MGI Sequence Detail 73671 C57BL/6J ±  kb
    transcript NR_029419 RefSeq | MGI Sequence Detail 2764 C57BL/6  
    polypeptide Q8C2L6 UniProt | EBI | MGI Sequence Detail 487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 33
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2145295
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 16
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:338312 Wang L, et al., TMEM161B modulates radial glial scaffolding in neocortical development. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2209983120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory