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Gigyf1 Gene Detail
Summary
  • Symbol
    Gigyf1
  • Name
    GRB10 interacting GYF protein 1
  • Synonyms
    Perq1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888677
    NCBI Gene: 57330
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137516810-137526197 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    19 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888677
 protein coding gene Chr5:137508470-137526197 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030229
 protein coding gene Chr5:142276237-142293630 (+)
A/J MGP_AJ_G0030197
 protein coding gene Chr5:136071590-136088966 (+)
AKR/J MGP_AKRJ_G0030130
 protein coding gene Chr5:140493027-140510341 (+)
BALB/cJ MGP_BALBcJ_G0030207
 protein coding gene Chr5:137447971-137458479 (+)
C3H/HeJ MGP_C3HHeJ_G0029923
 protein coding gene Chr5:141149205-141159718 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030659
 protein coding gene Chr5:147543068-147553564 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027877
 protein coding gene Chr5:130313909-130331361 (+)
CAST/EiJ MGP_CASTEiJ_G0029333
 protein coding gene Chr5:140546570-140564527 (+)
CBA/J MGP_CBAJ_G0029893
 protein coding gene Chr5:153401825-153419160 (+)
DBA/2J MGP_DBA2J_G0030044
 protein coding gene Chr5:135974819-135992369 (+)
FVB/NJ MGP_FVBNJ_G0029999
 protein coding gene Chr5:135184111-135199220 (+)
LP/J MGP_LPJ_G0030133
 protein coding gene Chr5:142736016-142753583 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030031
 protein coding gene Chr5:156228300-156245678 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030700
 protein coding gene Chr5:140345540-140363722 (+)
PWK/PhJ MGP_PWKPhJ_G0029046
 protein coding gene Chr5:135061784-135079261 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028882
 protein coding gene Chr5:137906512-137921818 (+)
WSB/EiJ MGP_WSBEiJ_G0029406
 protein coding gene Chr5:141073056-141090481 (+)



Homology
more
  • Human Ortholog
    GIGYF1, GRB10 interacting GYF protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GIGYF1, GRB10 interacting GYF protein 1
  • Synonyms
    GYF1, PERQ1
  • Links
    NCBI Gene ID: 64599
    UniProt: O75420

  • Chr Location
    7q22.1; chr7:100679507-100694250 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    21
  • cDNA Data
    37
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029714 Ensembl Gene Model | MGI Sequence Detail 9388 C57BL/6J ±  kb
transcript ENSMUST00000031727 Ensembl | MGI Sequence Detail 5440 Not Applicable  
polypeptide ENSMUSP00000031727 Ensembl | MGI Sequence Detail 1044 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:67990 Wilson MD, et al., Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Nucleic Acids Res. 2001 Mar 15;29(6):1352-65
  • Latest
    J:335507 Ding Z, et al., Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice. Biol Psychiatry. 2023 Mar 15;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory